Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Reexamination Certificate
2007-10-31
2009-06-09
Bunner, Bridget E (Department: 1647)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
C514S013800, C530S300000, C530S326000
Reexamination Certificate
active
07544360
ABSTRACT:
The present invention relates to antibodies raised against fragments of apolipoprotein B, in particular defined peptides thereof, for immunization or therapeutic treatment of mammals, including humans, against ischemic cardiovascular diseases, using one or more of said antibodies.
REFERENCES:
patent: 4970144 (1990-11-01), Fareed et al.
patent: 5408038 (1995-04-01), Smith et al.
patent: 5861276 (1999-01-01), Kwak et al.
patent: 5972890 (1999-10-01), Lees et al.
patent: 2004/0002111 (2004-01-01), Hansson et al.
patent: 99/08109 (1999-02-01), None
Fredrikson et al. Treatment with apo B peptide vaccine inhibits atherosclerosis in human apo B-100 transgenic mice without inducing an increase in peptide-specific antibodies. J Internal Med 264: 563-570, 2008.
George, J., et al. “Hyperimmunization of apo-E-defieicent mice with homologous malondialdehyde low-density lipoprotein suppresses early atherogenesis”, Atherosclerosis 138: 147-152, 1998.
Palinski, W., et al. “Immunzation of low density lipoprotein (LDL) receptor-deficient rabbits with homlogous malondialdehyde-modified LDL reduces athergenesis”, Proc. Natl. Acad. Sci. USA 92:821-825, Jan. 1995.
Fredrikson et al., “Identification of Immune Responses Against Aldehyde-Modified Peptide Sequences in ApoB Associated with Cardiovascular Disease” Arterioscl Thromb Vasc Biol.23: 872-878, May 2003.
Fredrikson et al., Arterioscl Thromb Vasc Biol.23: 879-884, May 2003.
Fredrikson et al., Autoimmunity 38(2): 171-179, 2005.
Goldberg et al., J Biol Chem 273(52): 35355-35361, 1998.
Goncalves et al., Arterioscl Thromb Vasc Biol.25: 1250-1255, 2005.
Ameli et al., Arterioscl Thromb Vasc Biol.25: 1250-1255, 2005.
Nilsson et al., J. Am Coll Cardiol 30: 1886-1891, 1997.
Freigang et al., “Immunization of LDL Receptor-Deficient Mice with Homologous Malondialdehyde-Modified and Native LDL Reduces Progression of Atherosclerosis by Mechanisms Other Than Induction of High Titers of Antibodies to Oxidative Neoepitopes” Arterioscl Thromb Vasc Biol.18: 1972-1982, 1998.
Zhou et al. Arterioscl Thromb Vasc Biol.21: 108-114, 2001.
Nilsson Jan
Shah Prediman K.
Bunner Bridget E
Cedars Sinai Medical Center
Forskarpatent I Syd
Matthew E. Connors LLP
LandOfFree
Peptide epitopes of apolipoprotein B does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Peptide epitopes of apolipoprotein B, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Peptide epitopes of apolipoprotein B will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4114181