Peptide derivatives usable as zinc endopeptidase 24-15 inhibitor

Details Peptide derivatives usable as zinc endopeptidase 24-15 inhibitor Peptide derivatives usable as zinc endopeptidase 24-15 inhibitor

1996-01-24

1998-07-07

Achutamurthy, Ponnathapura

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 7, 530330, 530304, 530302, 530300, 435212, A61K 3807, C07K 510

Patent

active

057769036

ABSTRACT:
Peptide derivatives usable as zinc endopeptidase 24-15 inhibitors.
These peptide derivatives have the following amino acid sequence:

REFERENCES:
patent: 5389612 (1995-02-01), Dive et al.
patent: 5500414 (1996-03-01), Dive et al.
Oorlowski et al, Biochem. J., vol. 261, pp. 951-958, (1989).
Barelli, et al., "Potent Inhibition of Endopeptidase 24.16 and Endopeptidase 24.15 by the Phosphonamide Peptide N-(phenylethylphosphonyl)-Gly-L-Pro-L-aminohexanoic Acid," Biochemical Journal--vol. 287(2) pp. 621-625 (1992).
Knight et al., "Thimet Oligopetidase Specificity: Evidence of Preferential Cleavage Near the C-Terminus and Product Inhibition From Kinetic Analysis of Peptide Hydrolysis," Biochemical Journal--vol. 308(1), pp. 145-150 (1995).
Bruno, et al., Phosphorus-Containing Peptides a Mixed Inhibitors of Endopeptidase 3.4.24.15 and 3.4.24.16: Effect on Neurotensin Degradation in vitro and in vivo., British Journal of Pharmacology--vol. 115(6), pp. 1053-1063 (1995).
Doulot, et al., "Synthesis and Analgesic Effects of e, a New Potent Inhibitor of Multiple Neurotensin/Neuromedin N Degrading Enzymes", Journal of Medicinal Chemistry--vol. 36(10), pp. 1369-1379 (1993).

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