Peptide derivatives, their production and use

Details Peptide derivatives, their production and use Peptide derivatives, their production and use

1983-04-18

1984-09-18

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Reduced antigenicity, reduced ability to bind complement, or...

2601125R, A61K 3700, C07C10352

Patent

active

044723830

ABSTRACT:
Novel peptide derivatives, inclusive of salts thereof, of the formula ##STR1## wherein A represents monocyclic or bicyclic hydrocarbon group, R.sup.1 and R.sup.3 are independently hydrogen, C.sub.1-4 alkyl or phenyl-C.sub.1-4 alkyl, and R.sup.2, R.sup.4 and R.sup.5 are independently hydrogen or C.sub.1-4 alkyl, have inhibitory activities of angiotensin converting enzyme and bradykinin decomposing enzyme, and are useful as antihypertensive agents.

REFERENCES:
patent: 4105776 (1978-08-01), Ondetti et al.
patent: 4256761 (1981-03-01), Suh et al.
Central Patents Index Basic Abstracts Journal, Section B Farmdoc, 94293 D/51 BO2 Tana 11/04/80, J56145-274.
Abstract of the 102nd Annual Meeting of Pharmaceutical Society of Japan, p. 382, 3M4-4, (published on Mar. 10, 1982).

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