Peptide derivatives, the preparation and their use as elastase i

Details Peptide derivatives, the preparation and their use as elastase i Peptide derivatives, the preparation and their use as elastase i

1984-05-14

1987-05-12

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514844, 530330, 530331, A61K 3702, C07K 508, C07K 510

Patent

active

046650539

ABSTRACT:
Lipopeptides of the formula, R--X--(P.sub.1).sub.x -(L--Ala--L--Ala--P.sub.2 --A wherein x is 0 or 1, R is the acyl residue of a hydrophobic carboxylic acid, P.sub.2 is, for instance, L--Ala, L--Val, L--Pro--L--Ala or L--Pro--L--Val, P.sub.1 is a residue of an amino acid or an oligopeptide formed from 2-8 amino acids, X represent a divalent group or a direct covalent bond and A represents the C-terminal portion (modified or not) of --(P.sub.1).sub.x --(Ala--Ala--P.sub.2). These lipopeptides can be used as elastase inhibitors.

REFERENCES:
patent: 4362716 (1982-12-01), Bouchaudon et al.
patent: 4439425 (1984-03-01), Tarcaay et al.
Hornebeck et al., Biological Pharmacology, 34, No. 18, 3315-3321 (1985).

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