Peptide derivatives of tachyplesin having antimicrobial activity

Details Peptide derivatives of tachyplesin having antimicrobial activity Peptide derivatives of tachyplesin having antimicrobial activity

1997-10-31

2000-01-18

Smith, Lynette R. F.

Multicellular living organisms and unmodified parts thereof and

Method of introducing a polynucleotide molecule into or...

The polynucleotide confers pathogen or pest resistance

514 2, 424405, 536 326, 536 231, 800298, 800278, 800295, 435 691, 435 701, 435468, 435410, 435418, 435419, C12N 1529, C12N 504, A01H 500, A01H 400

Patent

active

060159413

ABSTRACT:
Compositions comprising antimicrobial peptides are provided. The peptides are derivatives of tachyplesin having amino acid substitutions in which the four cysteine residues are replaced with hydrophobic amino acids. The compositions are useful in methods of the control of fungal and bacterial activity in agricultural and medical applications. Methods for making and using the compounds of the invention are additionally provided.

REFERENCES:
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Linthorst et al. Plant Cell. 1989. vol. 1: 285-291.
Liu et al. Proc. Natl. Acad. Sci. 1994. vol. 91: 1888-1892.
Zhong et al. 1995 Int. J. Pept. protein. Res. vol. 45: 337-347.
A. Gururaj Rao, (1995) Design and synthesis of amphipathic antimicrobial peptides, 45:337-347; Sep. 12, 1994.
R. J. Putnam and A.G. Rao (1994) Structure-funtion studies on the antimicrobial activity of tachyplesin through the synthesis of linear analogs.
A. Gururaj Rao, et al. (1992) Int. J. Peptide Protein Res. 40:507-514.
A. Gururaj Rao (1995) Antimicrobial Peptides MPMI vol. 8, No. 1, pp. 6-13.

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