Peptide derivatives having binding activity to modified low dens

Details Peptide derivatives having binding activity to modified low dens Peptide derivatives having binding activity to modified low dens

1995-02-28

1998-05-05

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 13, 514 14, 530324, 530326, 530327, A61K 3816, A61K 3810, C07K 1400, C07K 700

Patent

active

057474516

ABSTRACT:
Peptide derivatives represented by the formula (I): ##STR1## which can specifically bind to modified LDL in competition with scavenger receptors on macrophages and are useful in diagnosing, preventing and treating circulatory diseases caused by accumulation of modified LDL in macrophages.

REFERENCES:
Fields, "Mini-Collagens" (1993) Caplus # 1995:69258.
Fields, "Synthesis Collagen Sequences" (1993) Biosis # 94:12188.
C. Fields et al., "Solid-Phase Synthesis and Stability of Triple-Helical Peptides Incorporating Native Collagen Sequences", Biopolymers, vol. 33, Issue 10, pp. 1695-1707, Oct. 1993.
T. Tanaka et al., "A Synthetic Model of Collagen Structure taken from Bovine Macrophage Scavenger Receptor", FEBS 13257, vol. 334, No. 3, pp. 272-276, Nov. 1993.

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