Peptide derivatives as thrombin inhibitors

Details Peptide derivatives as thrombin inhibitors Peptide derivatives as thrombin inhibitors

1992-12-02

1997-03-25

Lukton, David

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 18, 530331, 548535, A61K 3805

Patent

active

056144997

ABSTRACT:
The invention relates to new competitive inhibitors of thrombin, pharmaceutical compositions containing the compounds as active ingredients, and the use of the compounds as anticoagulants for prophylaxis and treatment of thromboembolic diseases, according to the formula ##STR1## wherein A represents a methylene group, an ethylene group or a propylene group, which may be substituted or
A represents --CH.sub.2 --O--CH.sub.2 --, --CH.sub.2 --S--CH.sub.2 --, --CH.sub.2 --SO--CH.sub.2 --, or
A represents --CH.sub.2 --O--, --CH.sub.2 --S--, --CH.sub.2 --SO--, with the heteroatom functionality in position 4;
n is an integer 2 to 6; and
B represents --N(R.sup.6)--C(NH)--NH.sub.2, wherein R.sup.6 is H or a methyl group, or
B represents --S--C(NH)--NH.sub.2, or --C(NH)--NH.sub.2.

REFERENCES:
patent: 4568636 (1986-02-01), Svendsen
patent: 5037819 (1991-08-01), Han
patent: 5110812 (1992-05-01), Han
Chemical Abstracts, vol. 99, No. 25, 19 Dec. 1983 (Columbus, Ohio, USA), Bajusz, Sandor et al, "Inhibition of Thrombin with H- and Boc-D-Phe-Pro-Agm," p. 21, Abstract No. 205609.

Affiliated with

Also associated with

Rating

Peptide derivatives as thrombin inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Peptide derivatives as thrombin inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Peptide derivatives as thrombin inhibitors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2203452