Peptide derivatives as kininogenase inhibitors

Details Peptide derivatives as kininogenase inhibitors Peptide derivatives as kininogenase inhibitors

1995-06-07

1999-01-05

Huff, Sheela

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 19, 530331, A61K 3800

Patent

active

058563075

ABSTRACT:
The invention relates to compounds of the formula

REFERENCES:
patent: 4346078 (1982-08-01), Bajusz et al.
patent: 4568636 (1986-02-01), Svendsen
patent: 4703036 (1987-10-01), Bajusz et al.
patent: 4977168 (1990-12-01), Bernat et al.
patent: 5037819 (1991-08-01), Han
patent: 5110812 (1992-05-01), Han
patent: 5187157 (1993-02-01), Kettner et al.
patent: 5260307 (1993-11-01), Ackermann et al.
patent: 5273982 (1993-12-01), Alig et al.
patent: 5583146 (1996-12-01), Kimball et al.
patent: 5705487 (1998-01-01), Schacht et al.
Jackson et al. "Pharmacological Assessment of the Antithrombotic Activity of the Peptide Thrombin Inhibitor . . . ", J. of Pharm Exp. Ther. 261: 546-552, 1992.
Knabb et al. "In Vivo Characterization of a New Synthetic Thrombin Inhibitor", Thrombosis and Haemostatis, 67(1): 56-59, 1992.
Bajusz et al. "Inhibition of Thrombin with H-and Boc-D-Phe-Pro-Agm," Chem. Abs. 99: 205609w, 1983.
Klement et al. "The Effect of Thrombin Inhibitors on Tissue Plasminogen Activator Induced Thrombolysis in a Rat Model", Thrombosis and Haemostasis, 68(1): 64-68, 1992.
Marki et al., "The Anticoagulant and Antithrombotic Properties of Hirudins", Thrombosis and Haemostatis, 64(3): 344-348, 1990.
Broersma et al., "the Effect of Thrombin Inhibition in a Rat Arterial Thrombosis Model", Thrombosis Research, 64: 405-412, 1991.
Persson et al. Thorax 47: 993-1000, 1992.
Salomonson et al. Am. Rev. Resp. Dis. 146: 1535-1542, 1992.
Markwardt et al. Biochem. Pharm. 23: 2247-2256, 1974.
Malek et al. "Palladium-catalyzed synthesis of Cinnamylamides", J. Org. Chem. 47(27): 5395-5397, 1982.
Malek, et al. Chem. Abs. 98: 16353, 1983.
Glusa et al. "The influence of benzamidine derivaties on human platelet function," Thrombosis et Diathesis Haemorrhagica 31: 172-178, 1974.
Anderson and Lok, J. Organic Chem. 37: 3953, 1972.
Fareed et al., Ann. N.Y. Acad. Sci. 370: 765-784, 1981.
Geratz, J.D. "Inhibition of thrombin, plasmin and plasminogen compounds," Thrombosis et Diathesis Halmorrhagica 23 (3), 486-499, 1970.
Stewart et al: "Solid Phase Peptide Synthesis," Pierce Chemical Company, pp. 18-20 (with appendix).
Bajusz: "Interaction of Trypsin-like Enzymes With Small Inhibitors," pp. 277-298, Symposia Biologica Hungarica 25 (1984).

Affiliated with

Also associated with

Rating

Peptide derivatives as kininogenase inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Peptide derivatives as kininogenase inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Peptide derivatives as kininogenase inhibitors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-862399