Peptide derivatives and medicinal compositions

Details Peptide derivatives and medicinal compositions Peptide derivatives and medicinal compositions

2007-01-16

2007-01-16

Gupta, Anish (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S002600, C514S019300, C514S020800, C530S300000, C530S330000, C530S331000

Reexamination Certificate

active

10257238

ABSTRACT:
The present invention to novel nociceptin receptor agonists which are peptide derivatives represented by the following general formula (1):(in which A is alkylene, —CH2)nCO— or a group expressed by the following formula (2) or (3):wherein n represents an integer of 1 to 8; X and Y are same or different and each represents —CONH— or —CH2NH—; R1, R2and R3are same or different and each represents alkyl, aryl or heteroaryl; Z represents —CON(R4)R5or —CH2N(R4)R5; R4and R5are same or different and each represents hydrogen, alkyl, aryl or heteroaryl) or a pharmaceutically acceptable salt thereof. A pharmaceutical composition according to the present invention is useful as a nociceptin receptor agonist.

REFERENCES:
patent: 5332726 (1994-07-01), Klein et al.
patent: 5663295 (1997-09-01), Moreau et al.
patent: 6051685 (2000-04-01), Sakurada et al.
patent: 7-5034845 (1995-04-01), None
patent: WO 94/11018 (1994-05-01), None
patent: WO 95/01371 (1995-01-01), None
J Rosén, et al. A Human serine endopeptidase, purified with respect to activity against a peptide with phosphoserine in the P1′ position, is apparently identical with prolyl endopeptidase. (1991) J. Biol. Chem. 266, 3827-3834.
J Grehn, et al. Synthesis and cAMP dependent phosphorylation of Gva-Arg-Ala-Ser-NH-i-Bu. Pept. (1993) 1992, Proc. Eur. Pept. Symp., 22nd, Meeting Date, 1992, 798-799. Abstract only (56-57).
Pheng, L.H., et al “[Nphe1]nociceptin-1(1-13)NH2 selectively antagonizes nociceptin effects in the rabbit isolated ileum”, Apr. 7, 2000 European Journal of Pharmacology, vol. 397 (2/3), pp. 382-388 (6 pages).
Okada, Kazushi, et al., “Structure-activity studies on nociceptive peptides”, 1999, Tampakushitsu Kakusan Koso, vol. 44 (9), pp. 1369-1377 (10 pages).
English Language translation of relevance of above cited document.
Supplementary European Search Report (01921846.0-PCT/JP0103220) Nippon Shinyaku Co., Ltd.

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