Peptide derivatives and a method of measuring collagenase activi

Details Peptide derivatives and a method of measuring collagenase activi Peptide derivatives and a method of measuring collagenase activi

1977-01-21

1979-02-06

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

1951035R, C07C10352

Patent

active

041383940

ABSTRACT:
Peptide derivatives are obtained by eliminating the masking groups from masked peptide derivatives in which the guanidino group of an arginine residue and the carboxyl group of the arginine residue are masked. The guanidino group can be masked, for example, with a tosyl, nitro or benzyloxycarbonyl group, and the carboxyl group can be masked by converting it to an ester group, for example, a benzyl or t-butyl ester group. The masking groups can be eliminated using hydrogen fluoride, for example.

REFERENCES:
patent: 3849390 (1974-11-01), McGregor et al.
patent: 4016042 (1977-04-01), Svendsen
patent: 4028318 (1977-06-01), Aurell et al.
F. B. Reed, Chem. Abst. 86, 1977 p. 13027q.
N. Blumenkrantz, et al., Chem. Abst. 79, 1973 p. 89068e.
T. I. Morales, Chem. Abst. 84, 1976 p. 131887b.

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