Peptide derivatives

Chemistry: natural resins or derivatives; peptides or proteins; – Natural resins or derivatives – Rosin or derivative used as starting material in process – or...

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530328, 530329, 530402, 514 7, 514 15, 514 16, C09F 100, A61K 3800, C07K 500, C07K 700

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active

059170123

ABSTRACT:
Disclosed are a peptide derivative, which may be protected, containing a fluorescent group whose fluorescence is quenched with a quenching group in its molecule, the quenching group and a phosphoric acid group existing between said fluorescent group and said quenching group, in its molecule, a method for measuring protein phosphatase activity using the same as a substrate, and a reagent therefor.

REFERENCES:
patent: 5256677 (1993-10-01), Sham et al.
patent: 5387527 (1995-02-01), Sternberg
J. Michael Bishop, "Molecular Themes In Oncogenesis" (Cell, vol. 64, pp. 235-248, published Jan. 25, 1991).
Hyeongjin Cho, et al., "Purification and Characterization of a Soluble Catalytic Fragment of the Human Transmembrane Leukocyte Antigen Related (LAR) Protein Tyrosine Phosphatase from an Escherichia coli Expression System" (Biochemistry, 30, pp. 6210-6216, published 1991).
Zhizhuang Zhao, et al., "Continuous Spetrophotometric Assay of Protein Tyrosine Phosphatase Using Phosphotyrosine" (Analytical Biochemistry, 202, pp. 361-366, published 1992).
Nicholas K. Tonks, et al., "Purification of the Major Protein-tyrosine-phosphatases of Human Placenta" (The Journal of Biological Chemistry, vol. 263, p. 67226730, published May 15, 1988).

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