Peptide derivatives

Details Peptide derivatives Peptide derivatives

1992-09-04

1999-05-25

Tsang, Cecilia J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

C07C 7918

Patent

active

059070684

ABSTRACT:
The invention concerns pharmaceutically useful trifluoromethyl ketone substituted di-, tri- and tetra-peptide derivatives of the formulae Ia, Ib, Ic set out hereinafter, and salts thereof which are inhibitors of human leukocyte elastase. Also described herein are pharmaceutical compositions containing a peptide derivative and processes and intermediates for use in the manufacture of the peptide derivatives.

REFERENCES:
patent: 4596789 (1986-06-01), Dutta et al.
Imperiali, B. & Abeles, R. H. Biochemistry (1986), 25, 3760 (including twenty (20) pages of supplementary material).
Imperiali, B. & Ableles, R. H. Tetrahedron Lett. (1986), 27, 135.
Kingsbury, C.A., et al. J. Chem. Soc. Perkin Trans. II (1982), 867.
McBee, E. T., et al., J. Amer. Chem. Soc. (1956) 78, 4053.
Cook, D. J., et al, J. Amer. Chem. Soc. (1954), 76, 83.

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