Peptide derivatives

Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal

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424177, C07C10352, C07G 700

Patent

active

041285425

ABSTRACT:
There is provided peptide derivatives of the general formula ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 each represent the characterizing group of an .alpha.-amino acid of the type normally found in proteins; R.sup.4 represents a hydroxy or methyl group; n stands for zero, 1, 2 or 3; the configuration at the carbon atoms designated as (a), (b) and (c) is L (when R.sup.1 or R.sup.2 .noteq. H); and the configuration at the carbon atom designated as (d) is (R) (when R.sup.3 .noteq. H)
and pharmaceutically acceptable salts thereof.
The above compounds exhibit antibacterial activity against various microorganisms.

REFERENCES:
patent: 3826794 (1974-07-01), Flouret
patent: 3922262 (1975-11-01), Umezawa et al.
patent: 4016148 (1977-04-01), Atherton et al.

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