Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1977-07-05
1978-12-05
Phillips, Delbert R.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
424177, C07C10352, C07G 700
Patent
active
041285425
ABSTRACT:
There is provided peptide derivatives of the general formula ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 each represent the characterizing group of an .alpha.-amino acid of the type normally found in proteins; R.sup.4 represents a hydroxy or methyl group; n stands for zero, 1, 2 or 3; the configuration at the carbon atoms designated as (a), (b) and (c) is L (when R.sup.1 or R.sup.2 .noteq. H); and the configuration at the carbon atom designated as (d) is (R) (when R.sup.3 .noteq. H)
and pharmaceutically acceptable salts thereof.
The above compounds exhibit antibacterial activity against various microorganisms.
REFERENCES:
patent: 3826794 (1974-07-01), Flouret
patent: 3922262 (1975-11-01), Umezawa et al.
patent: 4016148 (1977-04-01), Atherton et al.
Atherton Frank R.
Hall Michael J.
Hassall Cedric H.
Lambert Robert W.
Ringrose Peter S.
Gould George M.
Hazel Biondel
Hoffman Frank P.
Hoffmann-La Roche Inc.
Phillips Delbert R.
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