Peptide derivatives

Details Peptide derivatives Peptide derivatives

2006-02-21

2006-02-21

McKane, Joseph K. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S018700, C514S258100, C514S277000, C514S311000, C514S314000, C514S345000, C514S395000, C530S331000, C544S283000, C546S113000, C546S134000, C546S250000, C548S305100

Reexamination Certificate

active

07001887

ABSTRACT:
A compound of Formula (1): whereinR1represents an amidinophenyl group, etc.;R2represents a hydrogen atom, etc.;R3represents a carbamoylalkyl group, etc.;R4represents a hydrogen atom, etc.;R5represents a benzyl group, etc.;R6represents a hydrogen atom, etc.; andR7represents an alkylsulfonyl group, etc.A crystal of a complex between factor VIIa/human soluble tissue factor and a low-molecular weight reversible factor VIIa inhibitor. A medium carrying a part or all of structure coordinate data of a complex between human factor VIIa/human soluble tissue factor and a low-molecular weight reversible factor VIIa inhibitor, obtainable by X-ray crystal structure analysis of the crystal. A method for computationally designing a low-molecular weight reversible factor VIIa inhibitor using the coordinate data.

REFERENCES:
patent: 5744487 (1998-04-01), Ohshima et al.
patent: 6287794 (2001-09-01), Safar et al.
patent: 6358960 (2002-03-01), Senokuchi et al.
patent: 6365617 (2002-04-01), McComsey et al.
patent: 6472393 (2002-10-01), Aliagas-Martin et al.
patent: 6586405 (2003-07-01), Semple et al.
patent: 0669317 (1995-08-01), None
patent: 0921116 (1999-06-01), None
patent: 1078917 (2001-02-01), None
patent: 2791683 (2000-10-01), None
patent: WO 00/15658 (2000-03-01), None
patent: WO 00/30646 (2000-06-01), None
patent: WO 00/35886 (2000-06-01), None
patent: WO 00/41531 (2000-07-01), None
patent: WO 00/58346 (2000-10-01), None
Banner, et al.The Crystal Structure of the Complex of Blood Coagulation factor VIIa with Soluble Tissue Factor Nature, vol. 380, No. 7 (Mar. 1996), pp. 41-46.
Banner, David.The Factor VIIa/Tissue Factor Complex, Thrombosis and Haemostasis, vol. 78, No. 1, (1997), pp. 512-515.
Böhm, Hans-Joachim.LUDI: Rule-Based Automatic Design of New Substituents for Enzyme Inhibitor Leads, Journal of Computer-Aided Molecular Design, vol. 6, (1992), pp. 593-606.
Dennis, et al.Peptide Exosite Inhibitors of Factor VIIa as Anticoagulants, Nature, vol. 404, (Mar. 2000), pp. 465-470.
Johnson, et al.Crystallization and Preliminary X-Ray Analysis of Active Site-Inhibited Human Coagulation Factor VIIa (des-GIa), Journal of Structural Biology, vol. 125, (1999), pp. 90-93.
Kemball-Cook, et al.Crystal Structure of Active Site-Inhibited Human Coagulation Factor VIIa (des-GIa), Journal of Structural Biology, vol. 127, (1999), pp. 213-223.
Kirchhofer, et al.Activation of Blood Coagulation Factor VIIa with Cleaved Tissue Factor Extracellular Domain and Crystallization of the Active Complex, PROTEINS, vol. 22, (1995), pp. 419-425.
MacKerell Jr. et al. “CHARMM: The Energy Function and its Parameterization.” inEncyclopedia of Computational Chemistry. (1998), vol. 1 A-D., pp. 271-277. ISBN: 047196588x.w.set.
Pike, et al.Structure of Human Factor VIIa and its Implications for the Triggering of Blood Coagulation, Proc. Natl. Acad. Sci. USA, vol. 96, (Aug. 1999), pp. 8925-8930.
Zhang, et al.Structure of Extracellular Tissue Factor Complexed with Factor VIIa Inhibited with a BPTI Mutant, J. Mol. Biol., vol. 285, (1999), pp. 2089-2104.

Affiliated with

Also associated with

Rating

Peptide derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Peptide derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Peptide derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3669245