Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1990-03-13
1991-10-08
Lee, Lester L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
548953, 548537, 548538, 548253, 530330, 530331, 546225, 546226, 546245, 546227, A61K 3764
Patent
active
050554506
ABSTRACT:
The invention concerns pharmaceutically useful trifluoromethyl ketone substituted di-, tri- and tetra-peptide derivatives of the formulae Ia, Ib, Ic set out hereinafter, and salts thereof, which are inhibitors of human leukocyte elastase. Also described herein are pharmaceutical compositions containing a peptide derivative and processes and intermediates for use in the manufacture of the peptide derivatives.
REFERENCES:
patent: 4596789 (1986-06-01), Dutta et al.
patent: 4910190 (1990-03-01), Bergeson et al.
Imperiali, B. & Abeles, R. H. Biochemistry (1986), 25, 3760 (including twenty (20) pages of supplementary material).
Imperial, B. & Abeles, R. H. Tetrahedron Lett. (1986) 27, 135.
Edwards Philip D.
Schwartz John A.
Stein Mark M.
Trainor Diane A.
Wildonger Richard A.
Davenport Avis
ICI Americas Inc.
Jackson Thomas E.
Lee Lester L.
Miano Rosemary M.
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