Peptide derivatives

Details Peptide derivatives Peptide derivatives

1993-04-07

1998-03-03

Walsh, Stephen

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 19, 530331, 530332, A61K 3806, A61K 3805

Patent

active

057234426

ABSTRACT:
The present invention relates to certain peptide derivatives, as described herein, which are human leukocyte elastase (HLE) inhibitors making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated, including treatment of tissue degenerative diseases such as pulmonary emphysema. The invention also includes intermediates useful in the synthesis of these peptide derivatives, processes for preparing them, pharmaceutical compositions containing such peptide derivatives and methods for their use.

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patent: 5164371 (1992-11-01), Edwards et al.
patent: 5194588 (1993-03-01), Edwards et al.
patent: 5221665 (1993-06-01), Skiles
Stein et al, Biochem. 26: 2682-2689, 1987.
J. L. Stanton et al., J. Med. Chem. (1983) 26, 1267-77.
J. T. Suh et al., J. Med. Chem. (1985) 28, 57-66.
S.M. Weldon et al., FASEB J. (1990) 4 (4), Abstract 5212.
B. Imperiali and R. H. Abeles, Biochemistry (1986) 23, 3760-67.

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