Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Glucagon; related peptides
Patent
1995-05-23
1999-02-09
Tsang, Cecilia J.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Glucagon; related peptides
530300, C07K 700
Patent
active
058696024
ABSTRACT:
The present invention relates to a pharmacologically active peptide hormone derivative in which the parent peptide hormone has been modified by introducing either a lipophilic substituent, W, in the N-terminal amino acid or a lipophilic substituent, Z, in the C-terminal amino acid of the parent peptide hormone or an analogue thereof, said lipophilic substituent having from 8 to 40 carbon atoms, has a protracted profile of action.
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Tenma T. et al., Abstract, Pharmaceutical Research, vol. 10, No. 10, pp. 1488-1492, Dialog Assn. No. 12616071 (1993).
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Cruz, M.E.M. et al., Chem. Abs., Proc. Int. Symp. Contr. Rel. Bioact. Mater., vol. 123, No. 10, pp. 345-347 (1995).
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Halstr.o slashed.m John
Hansen Per Hertz
Havelund Svend
Jonassen Ib
Kurtzhals Peter
Delacroix-Muirheid C.
Gregg, Esq. Valeta
Novo Nordisk A S
Tsang Cecilia J.
Zelson Esq. Steve T.
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