Peptide derivatives

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Glucagon; related peptides

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530300, C07K 700

Patent

active

058696024

ABSTRACT:
The present invention relates to a pharmacologically active peptide hormone derivative in which the parent peptide hormone has been modified by introducing either a lipophilic substituent, W, in the N-terminal amino acid or a lipophilic substituent, Z, in the C-terminal amino acid of the parent peptide hormone or an analogue thereof, said lipophilic substituent having from 8 to 40 carbon atoms, has a protracted profile of action.

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Tenma et al. Pharmaceutical Research. vol. 10. No. 10. Development of New Lipophilic Derivatives of Tetragastrin: Physiochemical Characteristics and Intestinal Absorption of Acyl-tetragastrin Derivatives in Rats. pp. 1488-1492, Oct. 1993.
Muranishi S. et al., Abstract, J. Control, vol. 19, pp. 179-188, Dialog Accn. No. 8421240 (1992).
Tenma T. et al., Abstract, Pharmaceutical Research, vol. 10, No. 10, pp. 1488-1492, Dialog Assn. No. 12616071 (1993).
Yodoya et al., Abstract, J. Pharmacology, vol. 271, No. 3, pp. 1509-1513, Dialog Assn. No. 13565514 (1994).
Cruz, M.E.M. et al., Chem. Abs., Proc. Int. Symp. Contr. Rel. Bioact. Mater., vol. 123, No. 10, pp. 345-347 (1995).
Martins, M.B. et al., Chem. Abs., Proc. Int. Symp. Contr. Rel. Bioact. Mater., vol. 118, No. 16, pp. 524-525 (1993).

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