Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues
Patent
1994-07-07
1997-08-12
Lipman, Bernard
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
5253282, 525374, 525379, 525380, 530311, 530334, A61K 3831
Patent
active
056567219
ABSTRACT:
The present invention provides a sugar derivative of a biologically active peptide, which derivative has a prolonged duration of action when compared to the non-sugar modified peptide, and contains at least on one of the amino acid units a sugar residue which is attached to an amino group thereof by a coupling other than a direct N-glycosidic bond, and additionally, when it is a condensation product of a carboxyl group containing sugar and a peptide with less than 8 amino acid units, by a coupling other than a direct amide bond.
REFERENCES:
patent: 4254023 (1981-03-01), Stewart et al.
patent: 4395403 (1983-07-01), Low et al.
Albert Rainer
Bauer Wilfried
Cardinaux Francois
Mergler Monika
Pless Janos
Honor Robert S.
Kassenoff Melvyn M.
Lipman Bernard
McGovern Thomas O.
Sandoz Ltd.
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