Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Reexamination Certificate
2006-02-21
2006-02-21
Desai, Rita (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
C514S567000, C564S015000, C568S017000
Reexamination Certificate
active
07001922
ABSTRACT:
The invention provides compounds and methods for using them to inhibit the growth of microorganism that expresses Peptide Deformylase, the compounds having the general formula:
REFERENCES:
patent: 4053638 (1977-10-01), Litchfield et al.
patent: 4083974 (1978-04-01), Turi
patent: 4339440 (1982-07-01), Bajusz et al.
patent: 5918568 (1999-07-01), Gjerløv
patent: 6110908 (2000-08-01), Guthery
patent: 6143790 (2000-11-01), Hallinan et al.
patent: 6159706 (2000-12-01), Shepard
patent: 6245750 (2001-06-01), Shepard
patent: 6339151 (2002-01-01), Shepard et al.
patent: 6448058 (2002-09-01), Patel et al.
patent: 6613879 (2003-09-01), Firestone et al.
patent: WO 98/13059 (1998-04-01), None
patent: WO 99/08110 (1999-02-01), None
patent: WO 99/37753 (1999-07-01), None
patent: WO 01/07454 (2001-02-01), None
patent: WO 02/089739 (2002-11-01), None
patent: WO 03/088913 (2003-10-01), None
International Preliminary Examination Report dated Dec. 15, 2004 for PCT/US2002/036124.
Boduszek Bogdan, English Abstract Synthesis of novel Phosphonopeptides derived from pyridylmethylphosphonate diphenyl esters.
Liu, et al. English Abstract “Synthesis and anticancer activities of new 5-fluorouracil-1-yl phosphonotripeptides”.
Copy of Written Opinion for PCT/US02/14500.
Copy of International Search Report for PCT/US02/36124.
Copy of European Supplemental Search Report for EP Appl. No. 02741696.5.
Apfel, C. M. et al. “Hydroxamic acid derivatives as potent peptide deformylase inhibitors and antibacterial agents”J. Med. Chem. (2000) 43:2324-2331.
Apfel, C. M. et al. “Peptide deformylase as an antibacterial drug target: Assays for detection of its inhibition inEscherichia colicell homogenates and intact cells”Antimicrobial Agents and Chemotherapy. (Apr. 2001a) 45(4):1053-1057.
Apfel, C.M. et al. “Peptide deformylase as an antibacterial drug target: Target validation and resistance development”Antimicrobial Agents and Chemotherapy(Apr. 2001b) 45(4):1058-1064.
Becker, A. et al. “Iron center, substrate recognition and mechanism of peptide deformylase”Nat. Struc. Biol. (Dec. 1998) 5(12):1053-1058.
Chan, M. K. et al. “Crystal structure of theEscherichia colipeotide deformylase”Biochemistry(1997) 36:13904-13909.
Chen, D. Z. et al. “Actinonin , a naturally occurring antibacterial agent, is a potent deformylase inhibitor”Biochemistry(2000) 39:1256-1262.
Clements, J. M. et al. “Antibiotic activity and characterization of BB-3497, a novel peptide deformylase inhibitor”Antimicrobial Agents and Chemotherapy(Feb., 2001) 45(2):563-570.
de Groot, F. M. H. et al. “Synthesis and biological evaluation of 2′-carbamate-linked and 2′-carbonate-linked prodrugs of paclitaxel: selective activation by the tumor-associated protease plasmin”J. Med. Chem. (2000) 43:3093-3102.
de Groot, F.M.H. et al. “Synthesis and Biological Evaluation of Novel Prodrugs of Anthracyclines for Selective Activation by the Tumor-Associated Protease Plasmin”J. Med. Chem. (1999) 42(25):5277-5283.
Dubowchik, G. M. and R. A. Firestone “Cathepsin B-sensitive depeptide prodrugs. 1. A model study of structural requirements for efficient release of doxorubicin”Bioor.&Med. Chem. Letts. (1998) 8:3341-3346.
Durand, D. J. et al. “Peptide aldehyde inhibitors of bacterial peptide deformylases”Archives of Biochemistry and Biophysics(Jul. 15, 1999) 367(2):297-302.
Giglione, C. et al. “Identification of eukaryotic peptide deformylases reveals universality of N-terminal protein processing mechanisms”The EMBO Journal(2000) 19(21):5916-5929.
Giglione, C. et al. “Peptide deformylase as a target for new generation, broad spectrum antimicrobial agents”Molecular Microbiology(2000) 36(6):1197-1205.
Hao, B. et al. “Structural basis for the design of antibiotics targeting peptide deformylase”Biochemistry(1999) 38(15):4712-4719.
Hu, Y.-J. et al. “H-phosphonate derivatives as novel peptide deformylase inhibitors”Bioor.&Med. Chem. Letts. (1998) 8(18):2479-2482.
Huntington, K. M. et al. “Synthesis and antibacterial activity of peptide deformylase inhibitors”Biochemistry(2000) 39(15):4543-4551.
Jayasekera, M. M. K. et al. “Novel nonpeptidic inhibitors of peptide deformylase”Archives of Biochem. and Biophy. (Sep. 15, 2000) 381(2):313-316.
Lackey, D. B. et al. “Enzyme-catalyzed therapeutic agent (ECTA) design: Activation of the antitumor ECTA compound NB 1011 by thymidylate synthase”Biochem. Pharmocol. (2001) 61:179-189.
Meinnel, T. “Vers une conception rationnelle de nouveaux agents antibactériens”Path. Biol. (Oct. 1999) 47(8):780-783.
Meinnel, T. et al. “Methionine as translation start signal: A review of the enzymes of the pathway inEscherichia coli” Biochemic(1993) 75(12):1061-1075.
Ragusa S. et al. “Control of peptide deformylase activity by metal cations”J. Mol. Biol. (1998) 280:515-523.
Rajagopalan, P. T. R. and D. Pei “Oxygen-mediated inactivation of peptide deformylase”Bio. Chem. (Aug. 28, 1998) 273(35):22305-22310.
Rajagopalan, P. T. R. et al. “Purification, characterization, and inhibition of peptide deformylase fromEscherichia coli” Biochem. (1997) 36(45):13910-13918.
Wei, Y. and D. Pei “Continuous spectrophotometric assay of peptide deformylase”Analytical Biochem. (1997) 250(1):29-34.
Wei, Y. and D. Pei “Activation of antibacterial prodrugs by peptide deformylase”Bioor.&Med. Chem. Letts. (2000a) 10(10):1073-1076.
Wei, Y. et al. “Identification of a potent peptide deformylase inhibitor from a rationally designed combinatorial library”J. Comb. Chem. (2000b) 2(6):650-657.
Ballatore Carlo
Doppalapudi Venkata Ramana
Sergeeva Maria V.
Celmed Oncology (USA), Inc.
Desai Rita
Foley & Lardner LLP
LandOfFree
Peptide deformylase activated prodrugs does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Peptide deformylase activated prodrugs, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Peptide deformylase activated prodrugs will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3654660