Peptide-containing liposomes, immunogenic liposomes and methods

Details Peptide-containing liposomes, immunogenic liposomes and methods Peptide-containing liposomes, immunogenic liposomes and methods

1995-05-25

1999-06-29

Achutamurthy, Ponnathapura

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

4241841, A61K 9127, A61K 3900

Patent

active

059165880

ABSTRACT:
A high integrity liposome comprising at least one stabile lipid and at least one peptide-like therapeutic agent associated with the liposome, adapted for parenteral administration to an animal, including a human, and method according to manufacture and use.
Immunizing dosage forms comprising a liposome and an immunogen, wherein the liposome and immunogen are present in an immunization dose. Additionally, a dosage form, including such form particularly adapted to producing an immune response, comprising a salt according to an organic acid derivative of a sterol and an immunogen are present in an immunization dose, and method according to uses is disclosed. Further, a dosage form, including such form particularly adapted to producing an immune response, comprising dimyristolyphosphatidylcholine (DMPC)/cholesterol liposomes, optionally in an aluminum hydroxide gel, and an immunogen wherein the DMPC/cholesterol and immunogen are present in an immunization dose, and method according to use.

REFERENCES:
patent: 4053585 (1977-10-01), Allison et al.
patent: 4117113 (1978-09-01), Allison et al.
patent: 4201767 (1980-05-01), Fullerton et al.
patent: 4396630 (1983-08-01), Riedl et al.
patent: 4416872 (1983-11-01), Alving et al.
patent: 4522803 (1985-06-01), Lenk et al.
patent: 4522811 (1985-06-01), Eppstein et al.
patent: 4565696 (1986-01-01), Heath et al.
patent: 4578269 (1986-03-01), Morein
patent: 4588578 (1986-05-01), Fountain et al.
patent: 4598051 (1986-07-01), Papahadjopoulos et al.
patent: 4603044 (1986-07-01), Geho et al.
patent: 4661346 (1987-04-01), New et al.
patent: 4663161 (1987-05-01), Mannino et al.
patent: 4721612 (1988-01-01), Janoff et al.
patent: 4722842 (1988-02-01), Stallcup et al.
patent: 4743583 (1988-05-01), Speaker et al.
patent: 4745074 (1988-05-01), Schreier et al.
patent: 4752425 (1988-06-01), Martin et al.
patent: 4761288 (1988-08-01), Mezei
patent: 4762720 (1988-08-01), Jizomoto
patent: 4789735 (1988-12-01), Frank et al.
patent: 4806352 (1989-02-01), Cantrell
patent: 4826687 (1989-05-01), Nerome et al.
patent: 4891208 (1990-01-01), Janoff et al.
patent: 5013555 (1991-05-01), Collins
patent: 5026557 (1991-06-01), Estis et al.
patent: 5049390 (1991-09-01), Wojdani
patent: 5100662 (1992-03-01), Bolcsak et al.
Almeida, et al., "Formation of Virosomes from Influenza Subunits and Liposomes", 1975, The Lancet, 899-901.
Alving, et al., "Preparation and Use of Liposomes in Immunological Studies", Chapter 11, Liposome Technology, vol. II, pp. 157-175 (date unknown).
Alving, C., "Liposomes as Carriers for Vaccines", 1987, Liposomes: From Biophysics to Therapeutics, 195-218.
Alving, et al., "Effectiveness of Liposomes as Potential Carriers of Vaccines: Application to Cholera Toxin and Human Malaria Sporozite Antigen", 1986, Vaccine, 4:166-172.
Arrowsmith, et al., "The in vivo Release of Cortisons Esters from Liposomes and the Intramuscular Clearance of Liposomes", 1984, Int. J. Pharma, 20:347-362.
Davis, et al., "Liposomes as Adjuvants with Immunogpurified Tetanus Toxoid" Influence of Liposomal Characteristics, 1987, Immunology 61:229-234.
Davis, et al., "Liposomes as adjuvants with Immunopurified Tetanus Toxoid: the Immune Response", 1986/1987; Immunology Letters, 14:341-348.
Eppstein, et al., "Controlled-Release and Localized Targeting of Interferon", 1986, Plenum Press, NY Ed. Davis, et al., 277-283.
Gregoriadis, et al., "Liposomes as immunological adjuvants: antigen incorporation studies", 1987, Vaccine 5:145-1512.
Jackson, et al., Intramuscular Absorption and Regional Lymphatic Uptake of Liposome-Entrapped Inulin, 1981, Drug. Met. Dis, 9:535-540.
Kramp, et al., "Liposomal Enhancement of the Immunogenicity of Adenovirus Tyupe 5 Hexon and Fiber Vaccines", 1979, Infec. and Immun. 25(2): 771-773.
Latif, et al., "The Effect of Surface-coupled Antigen of Liposomes in Immunopotentiation", 1987, Immunology Letters, 15:45-51.
North, et al., "Purified Epstein-Barr Virus Mr 340,000 Glycoprotein Induces Potent Virus-neutralizing Antibodies When Incorporated in Liposomes", 1982, Proc. Natl. Acad. Sci, 79:7504-7508.
Richards, et al., Liposomes, Lipid A, and Aluminum Hydroxide Enhance the Immune Response to a Synthetic Malaria Sprozoite Antigen, 1988, Infection and Immunity, 56:682-686.
Rooijen, et al., "Use of Liposomes as Biodegradable and Harmless Adjuvants", 1983, Methods in Enzymology, 93:83-95.
Sanchez, et al., "Humoral and Cellular Immunity to Hepatitis B Virus-Derived Antigens: Comparative Activity of Freund Complete Adjuvant, Alum, and Liposomes", 1980, Infection and Immunity, 30:728-733.

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