Peptide constructs for treating autoimmune and related diseases

Details Peptide constructs for treating autoimmune and related diseases Peptide constructs for treating autoimmune and related diseases

2007-04-03

2007-04-03

Chan, Christina (Department: 1644)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

C530S402000, C530S403000

Reexamination Certificate

active

10111602

ABSTRACT:
Conjugated peptides include a first peptide component which is an antigen associated with autoimmune disease, allergy, asthma or transplantation rejection and binds to an antigen-specific receptor on a T cell, and a second peptide component which corresponds to an “antigen presenting molecule”, namely, a peptide binding to a T cell surface receptor, which would normally promote T cell activation when the first peptide is bound to its antigen-specific T cell receptor. However, in this invention, the second peptide component has an amino acid sequence which is a modification of an antigen presenting T cell binding peptide, such modification blocking or inhibiting the engagement of receptor sites on the T cell surface (other than the antigen-specific T cell receptor). As a result, T cell activation is prevented, and is directed through antigen-specific T cell receptor occupation, without T cell activation, leading to antigen-specific T cell anergy and cell death. Administration of the conjugated peptide to an animal will provide protection against disease associated with the first peptide component, resulting from the elimination of the T cells bearing the antigen-specific receptors for that anti genic peptide. The conjugated peptides of this invention provide antigen-specific protection without impairing the immune response to other antigens.

REFERENCES:
patent: 6096537 (2000-08-01), Chappel
patent: 6100377 (2000-08-01), Greene
patent: 6287565 (2001-09-01), Zimmerman et al.
patent: 6358751 (2002-03-01), Benichou et al.
patent: WO 98/08416 (1998-02-01), None
patent: WO 99/16710 (1999-04-01), None
UniProt Accession #O19507, Jan. 1, 1999, one page.
UniProt Accession #O00664, Jul. 1, 1997, one page (same page as “U”).
Anderton, S. M. Immunology 2001, vol. 104,pp. 367-376.

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