Peptide conjugated anti-cancer prodrugs

Details Peptide conjugated anti-cancer prodrugs Peptide conjugated anti-cancer prodrugs

2006-11-14

2006-11-14

Siew, Jeffrey (Department: 1642)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

C514S002600

Reexamination Certificate

active

07135547

ABSTRACT:
The present invention relates to pharmaceutical compositions that include a targeting peptide, a protease specific cleavable peptide, and a chemotherapeutic drug that when conjugated are substantially inactive, but upon degradation of the cleavable sequence by a proteolytic enzyme abundant in or within the target cancer cell, the chemotherapeutic drug is released and becomes active, and to methods of use of these compositions for treatment of cancer.

REFERENCES:
patent: 6416758 (2002-07-01), Thorpe et al.
Maeda et al (Cancer, 1996, 77(5):858-863).

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