Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Insulin; related peptides
Patent
1993-11-29
1995-08-15
Warden, Jill
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Insulin; related peptides
530304, 530345, 530399, 530394, 530409, A61K 3514, A61K 3800, A61K 3828, A61K 700, C07K 700
Patent
active
054420431
ABSTRACT:
The present invention provides a conjugate capable of passing the blood-brain barrier comprising a bioactive peptide or protein incapable of passing the blood-brain barrier and a carrier peptide which exhibits substantially no bioactivity and which is capable of passing the blood-brain barrier. The conjugate makes it possible to allow a bioactive peptide or protein incapable of passing the blood-brain barrier to easily pass the blood-brain barrier for uniform transport to the brain without any side effect of the carrier peptide.
REFERENCES:
patent: 4801575 (1989-01-01), Pardridge
Pardridge, W. M. (1992) Pharmacol. Toxicol. 7, 3-10 Recent Developments in Peptide Drug Delivery to the Brain.
Fukuta Makoto
Iinuma Satoshi
Okada Hiroaki
Prickril Benet
Takeda Chemical Industries Ltd.
Warden Jill
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