Peptide compounds having substance P antagonism, processes for p

Details Peptide compounds having substance P antagonism, processes for p Peptide compounds having substance P antagonism, processes for p

1990-04-06

1992-11-17

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 18, 514 17, 530330, A61K 3700, A61K 3702, C07K 500, C07K 700

Patent

active

051643723

ABSTRACT:
Peptide compounds having Substance P antagonism of the formula: ##STR1## wherein R.sup.1 is lower alkyl, aryl, arylamino, pyridyl, pyrrolyl, pyrazolopyridyl, quinolyl, or a group of the formula: ##STR2## wherein the symbol of a line and dotted line is a single bond or a double bond; X is CH or N; Z is O, S or NH; R.sup.2 is hydrogen or lower alkyl; R.sup.3 is hydrogen or hydroxy; R.sup.4 is lower alkyl which may have suitable substituent(s); R.sup.5 is ar(lower)alkyl which may have suitable substituent(s) or pyridyl(lower)alkyl, or R.sup.4 and R.sup.5 are linked together to form benzene-condensed lower alkylene; A is an amino acid residue excepting D-Trp, which may have suitable substituent(s); and Y is bond, lower alkylene or lower alkenylene;
and their pharmaceutically acceptable salts are disclosed.

REFERENCES:
patent: 4228077 (1980-10-01), Ondetti et al.
patent: 4254107 (1981-03-01), Veber et al.
patent: 4404135 (1983-09-01), Jones
patent: 4680283 (1987-07-01), Veber et al.
patent: 4791102 (1988-12-01), Bernat et al.
patent: 4839465 (1989-06-01), Singh et al.

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