Peptide compounds derived from a shifted ORF of the iCE gene

Details Peptide compounds derived from a shifted ORF of the iCE gene Peptide compounds derived from a shifted ORF of the iCE gene

2005-04-05

2005-04-05

Nickol, Gary B. (Department: 1642)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C530S300000, C514S002600

Reexamination Certificate

active

06875844

ABSTRACT:
The present invention relates to a peptide compound which causes a tumor-specific T response, and which comprises a sequence of at least 8 consecutive amino acids of the peptide sequence encoded by a frame-shifted sequence of the iCE gene. The invention also relates to a pharmaceutical composition comprising said peptide compound and to the use of these compounds for manufacturing a medicinal product intended for treating cancer, in particular for treating solid tumors.

REFERENCES:
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patent: WO 9855133 (1998-12-01), None
patent: WO 9918206 (1999-04-01), None
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Ronsin, C. et al. “A non-AUG-defined alternative open reading frame of the intestinal carboxyl esterase mRNA generates an epitope recognized by renal cell carcinoma-reactive tumor-infiltrating lymphocytes in situ.”Journal of Immunology(1999), vol. 163, No. 1, pp. 483-490.

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