Peptide compounds

Details Peptide compounds Peptide compounds

1983-11-28

1985-02-12

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

2601125R, 514 18, A61K 3700, C07C10352

Patent

active

044990812

ABSTRACT:
The invention provides compounds of the general formula: ##STR1## (in which R.sup.1 is the residue of glycine or D-alanine, and all other amino-acid residues are in the L-form, X.sup.1 and X.sup.2, which may be the same or different, are OH or NH.sub.2 and n is 0 or 1) and their physiologically acceptable salts.
The compounds of the invention are capable of inhibiting the myelopoietic system of humans and animals, thereby protecting said system against attack by cytotoxic drugs.

REFERENCES:
patent: 3792032 (1974-02-01), Bernardi et al.
patent: 3928306 (1975-12-01), Uchiyama et al.
patent: 4235772 (1980-11-01), Lundin et al.
patent: 4411890 (1983-10-01), Momany
patent: 4412988 (1983-11-01), Gasc et al.
Notizen, vol. 37, pp. 1297-1300 (1982).
Chem. Abstr., vol 99, (1983) 1022q.
P. Foa, L. Lombardi, A. Ciani, F. Chillemi, A. T. Maiolo, E. E. Polli and B. M. Cesana, "A Synthetic Pentapeptide Inhibiting Normal and Leukaemic Myelopoiesis In Vitro", IRCS Med. Sci.: Libr. Compend., 1983, 11 (3), pp. 272-273.

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