Peptide compound and a pharmaceutically acceptable salt thereof

Details Peptide compound and a pharmaceutically acceptable salt thereof Peptide compound and a pharmaceutically acceptable salt thereof

1988-04-29

1992-05-05

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514400, 514419, 514423, 514626, 548344, 548496, 548537, 562564, 562565, 562442, 562445, 562557, 562559, A61K 31415, C07C 924, C07D23361

Patent

active

051107970

ABSTRACT:
Peptide compounds of formula (I): ##STR1## wherein A is hydrogen or an amino-protecting group; X is a member selected from the group consisting of Gly, Glu, Tyr, Asp, Phe, Ile, Ala, Pro, Leu, Hyp, Val, His, Arg, Ser, Thr, Pyr, Trp, 5-HTP, Cys, Met, .tau.-Glu, .beta.-Asp; Y is a (CH.sub.2).sub.3-6 or (CH.sub.2).sub.3-6 having an hydroxy group; R is an hydroxy group or an oxygen atom with a carboxy-protecting group; are useful as neurotropic agents.

REFERENCES:
patent: 5021430 (1991-06-01), Ksander
Sadano et al, "Janolusimide . . . ", Tetrahedron Lett., vol. 27, No. 22, pp. 2505-2508, 1986.
The McGraw-Hill Dictionary of Scientific & Technical Terms, p. 330.
Chem Abstracts 101:121904b, L-Ornithyltairine, Toda et al from J. Agric Food Chem, 1984, 32(5), 992-6.

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