Peptide compositions for coating metal medical devices with...

Details Peptide compositions for coating metal medical devices with... Peptide compositions for coating metal medical devices with...

2011-07-05

2011-07-05

Shafer, Shulamith H (Department: 1647)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

C514S001100, C514S021300, C514S021400, C514S021500, C514S021600, C514S021700, C514S021800, C530S300000, C530S304000, C530S324000, C530S326000, C530S327000, C530S328000, C530S329000

Reexamination Certificate

active

07972615

ABSTRACT:
The presently disclosed subject matter provides compositions comprising a first substrate-binding domain (a peptide or a polymer) having binding affinity for a tissue or a medical device, a second substrate-binding domain having binding affinity for a target molecule, and the target molecule. In some embodiments, the first and second substrate-binding domains are covalently linked. The first and second substrate-binding domains are covalently coupled to at least one hydrophobic interaction tag, negatively charged interaction tag, or positively charged interaction tag. When the substrate-binding domains are combined and coated onto the tissue or medical device, the hydrophobic interaction tags interact with each other and the charged interaction tags interact with the oppositely charged interaction tags or the oppositely charged substrate binding polymers, to form a macromolecular network of non-covalently coupled substrate-binding domains to load the target molecule onto the tissue or medical device.

REFERENCES:
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patent: 6428579 (2002-08-01), Valentini
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patent: 2004/0106544 (2004-06-01), Cooper
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patent: 2005/0260275 (2005-11-01), Patt
patent: 2006/0263830 (2006-11-01), Grinstaff
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patent: 2006007368 (2006-01-01), None
Written Opinion for the International Searching Authority for PCT/US09/38573, Jun. 15, 2009.

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