Peptide compositions and method of radiolabeling

Details Peptide compositions and method of radiolabeling Peptide compositions and method of radiolabeling

1997-12-12

1998-09-08

Hollinden, Gary E.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

In an organic compound

530328, 424 137, 424 111, A61K 5100, A61M 3614

Patent

active

058041575

ABSTRACT:
This invention relates to radiolabeled peptide compositions for radiopharmaceutical use and, more specifically, to radiolabeled peptides for diagnostic or therapeutic use having an unmodified carboxy terminal amino acid. The radiopharmaceutical composition may be used for targeting a selected biological site. The radiolabeled peptide is characterized by having its carboxy terminal amino acid in its carboxylic acid form and the peptide is coupled to a diagnostic or therapeutic radionuclide by a chelating agent. The radiopharmaceutical composition preferably comprises a radiolabeled peptide selected from the group consisting of somatostatin, an analog of somatostatin, a derivative of somatostatin and peptides capable of binding to the somatostatin receptor, where the peptide is coupled to a diagnostic or therapeutic radionuclide by a chelating agent has its carboxy terminal amino acid in its carboxylic acid form.

REFERENCES:
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patent: 5650134 (1997-07-01), Albert et al.
patent: 5705143 (1998-01-01), Bower et al.
Bauer et al. (1982), Life Sciences, vol. 31, pp. 1133-1140, "SMS 201-995: A Very Potent and Selective Octapeptide Analogue of Somatostatin with Prolonged Action".

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