Peptide composition as anitgen for detection of antibodies to HT

Details Peptide composition as anitgen for detection of antibodies to HT Peptide composition as anitgen for detection of antibodies to HT

1987-01-09

1989-05-23

Nucker, Christine M.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

435 7, 435805, 435810, 530326, 530327, 422 61, C07K 708, C07K 710, C12Q 170, B65D 6900

Patent

active

048330710

ABSTRACT:
The present invention relates to a method for the detection and diagonosis of ATL (adult T cell leukemia/lypmphoma) condition by the use of chemically synthesized peptide composition. The peptide composition comprises peptides having amino acid sequences corresponding to segments of the envelope protein, p21, of HTLV-I and mixtures thereof. The peptide composition is highly immunoreactive with antibodies in sera of patients with ATL.
The detection method includes an enzyme-linked immunosorbent assey (ELISA), an immunoradiometric assay (IRMA), and other forms of immunoassay procedures such as enzyme immuno blotting assay on nitrocellulose paper and hemagglutination assay using the peptide composition as the antigen. The preferred detection method is ELISA.

REFERENCES:
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