Peptide capable of being recognized by antibodies recognizing th

Details Peptide capable of being recognized by antibodies recognizing th Peptide capable of being recognized by antibodies recognizing th

1996-07-25

1999-11-16

Wortman, Donna C.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

436518, 530328, 530329, 530413, C12Q 170, G01N 33543

Patent

active

059855410

ABSTRACT:
Polypeptide able to react specifically with an antibody directed against the C33 antigen of hepatitis C virus, and that has a peptide sequence including all or part of the Asp-Gly-Ala-Lys-Phe-Ser-Ser-Arg-Leu-Gly-Ala-Ala-Gly-Ala SEQ ID NO: 1 sequence, or a sequence derived from this peptide sequence recognized by the antibody. This polypeptide has applications for detection of C33 antigen and anti-C33 antibodies.

REFERENCES:
Y. Khudyakov et al., "Linear B-Cell Epitopes of the NS3-NS5 Proteins of the Hepatitis C Virus as Modeled with Synthetic Peptides", Virology, vol. 206, pp. 666-672 (1995).
J. Scott et al., "Search for Peptide Ligands with an Epitope Library", Science, vol. 249, pp. 386-390, Jul. 27, 1990.
Farci et al., "Lack of Protective Immunity Against Reinfection with Hepatitis C Virus", Science, 258:135-140, Oct. 2, 1992.

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