Peptide boronic acid inhibitors of trypsin-like proteases

Details Peptide boronic acid inhibitors of trypsin-like proteases Peptide boronic acid inhibitors of trypsin-like proteases

1988-04-06

1993-02-16

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 19, 514 20, 530330, 530331, 548110, 548405, 562 7, A61K 3702, C07K 506, C07K 508, C07K 510

Patent

active

051871572

ABSTRACT:
Peptides comprising C-terminal boronic acid derivatives of lysine, ornithine, and arginine, homoarginine and corresponding isothiouronium analogs thereof, are reversible inhibitors of trypsin-like serine proteases such as thrombin, plasma kallikrein and plasmin.

REFERENCES:
patent: 4318904 (1982-03-01), Shaw et al.
patent: 4499082 (1985-02-01), Shenvi et al.
patent: 4537773 (1985-08-01), Shenvi
Phillipp et al., Federation Proceedings, 46(6): 2223, abstract #1737 (1987).
Koehler et al., Biochemistry 10: 2477-2483 (1971).
Matteson et al., J. Am. Chem. Soc. 103: 5241-5242 (1981).
Lienhard, in Enzyme Inhibitors as Drugs, Sandler, ed., University Park Press, Baltimore pp. 43-51 (1980).
Kinder et al., J. Med. Chem. 28: 1917-1925 (1985).
Baumgarten et al., J. Immun. 137: 977-982 (1986).
Wachtfogel et al., Blood 67: 1731-1737 (1986).
Markwardt, TIPS 153-157 (1980).
Green et al., Thromb. Res. 37: 145-153 (1985).
Kettner et al., in Methods in Enzymology, Lorand, ed., Academic Press, New York, 80: 826-842 (1981).
Bajusz et al., Int. J. Peptide Protein Res. 12: 217-221 (1979).
Tremoli et al., Thromb. Res. 23: 549-553 (1981).
Kikumoto et al., Biochemistry 23: 85-90 (1984).
Kaiser et al., Thromb. Res. 43: 613-620 (1986).
Sturzebecher et al., Thromb. Res. 29: 635-642 (1983).
D. S. Matteson et al., Organometallics 3, 1284-1288 (1984).
D. S. Matteson et al., J. Am. Chem. Soc. 103, 5242-5245 (1981).
D. K. Kinder and J. A. Katzenellenbogen, J. Med. Chem. 28, 1917-1925. (1985).

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