Peptide boronic acid inhibitors of trypsin-like proteases

Details Peptide boronic acid inhibitors of trypsin-like proteases Peptide boronic acid inhibitors of trypsin-like proteases

1992-03-09

1993-09-07

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 14, 514 15, 514 16, 514 17, 530327, 530328, 530329, 530330, A61K 3702, C07K 510, C07K 706, C07K 708

Patent

active

052429040

ABSTRACT:
Peptides comprising C-terminal boronic acid derivatives of lysine, ornithine, and arginine, homoarginine and corresponding isothiouronium analogs thereof, are reversible inhibitors of trypsin-like serine proteases such as thrombin, plasma kallikrein and plasmin.

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