Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2006-10-03
2006-10-03
Le, Long V. (Department: 1641)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007200, C435S007900, C435S007920, C435S007930, C436S534000, C436S538000, C436S015000, C436S086000
Reexamination Certificate
active
07115378
ABSTRACT:
A method for identifying and quantifying peptides resulting from enzyme cleavage of collagen type II by mass spectrometric analysis to detect characteristic peptide fragments of a carboxy-terminus having known mass to charge ratios to identify the peptide having that carboxy-terminus. Identification and quantification of the peptides in a biological sample is used to assess activity of proteolytic enzymes in diseases or physiological conditions such as osteoarthritis and rheumatoid arthritis and to assess the efficacy of enzyme blocking agents.
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Duffin Kevin L.
Dufield Dawn R.
Howard Carol Pearcy
Nemirovskiy Olga V.
Sunyer Teresa
Cheu Jacob
Le Long V.
Pharmacia Corporation
Pharmacia Corporation
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