Peptide based nucleic acid surrogates

Details Peptide based nucleic acid surrogates Peptide based nucleic acid surrogates

1996-05-14

1998-03-24

Chambers, Jasemine C.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

514 2, 514 44, 536 231, 536 243, 536 241, C07K 200, A61K 3802

Patent

active

057314160

ABSTRACT:
The present invention relates to the development of a new class of oligonucleotide surrogates capable of sequence specific binding to simple stranded DNA and RNA as well as to double stranded DNA targets. More repeating structural units for a number of the nucleic acid surrogates of the present invention. Once synthesized (in suitably protected form), the monobasic units are linked together via peptide bonds to produce the required oligomeric structures having defined nucleobase sequences. These nucleic acid surrogates may then be utilized for use as antisense/antigene probes and/or drug carriers.

REFERENCES:
Garner et al., Tetrahedron Letters 34, pp. 1275-1278 (1993).
Weller et al., J. Org. Chem 56, pp. 6000-6006 (1991).
Timoshch et al, Zh. Obschch. Khim. 58(1988), p. 2140.
Uhlmann et al., Chemical Reviews 90(1990), pp. 544-584.
Plattner et al., in Drug Discovery Technologies, 1990, Ellis Harwood Limited, pp. 92-126.
Tyaglow, B.V. et al., Zh. Obshch. Khim. (1987) 57, 2124.
Hyrup et al., "Structure-activity studies of the binding of modified peptide nucleic acids (PNAs) to DNA", J. Am. Chem. Soc. 116: 7964-7970, 1994.

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