Peptide based-compounds

Details Peptide based-compounds Peptide based-compounds

2011-03-01

2011-03-01

Jones, D L (Department: 1618)

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Diagnostic or test agent produces in vivo fluorescence

C424S001110, C424S001650, C424S001690, C424S009100

Reexamination Certificate

active

07897142

ABSTRACT:
The invention relates to new peptide-based compounds and their use in diagnostic optical imaging techniques. More specifically the invention relates to the use of such peptide-based compounds as targeting vectors that bind to receptors associated with angiogenesis. The compounds are labelled with at least one cyanine dye reporter and may be used as contrast agents in optical imaging in diagnosis of angiogenesis-related diseases.

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patent: 2005/003166 (2005-01-01), None
PCT/NO2005/000210 International Search Report and Written Opinion dated Oct. 12, 2005.
Chen, X, et.al., “In vivo near-infrared fluorescence imaging of integrin .alpha.v.beta.3 in braintumor xenografts” Cancer Research vol. 64, No. 21, Nov. 1, 2004 pp. 8009-8014.
Achilefu, S, et.al. “Synergistic effects of light-emitting probes and peptides for targeting and monitoring integrin expression” Proceedings of the National Academy of science, USA, vol. 102, No. 22, May 31, 2005 pp. 7976-7981.

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