Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving viable micro-organism
Patent
1987-05-19
1989-05-23
Kepplinger, Esther M.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving viable micro-organism
435 32, 435 70, 435 71, 4352521, C12Q 102, C12Q 118, C12P 2102, C12P 2104, C12N 120
Patent
active
048330760
ABSTRACT:
Peptides of the formula ##STR1## wherein R is CH.sub.3 --(CH.sub.2).sub.6, CH.sub.3 --(CH.sub.2).sub.4 --CH.dbd.CH--(CH.sub.2).sub.2 and CH.sub.3 (CH.sub.2).sub.8 having antibiotic and antitumor activity are prepared by cultivation of the novel microorganism Polyangium brachysporum. Enzymatic hydrolysis of those peptides gives other peptides useful as intermediates in the preparation of peptides having activity as antibiotics and/or antitumor agents.
REFERENCES:
patent: 4062943 (1977-12-01), Lindberg
patent: 4742047 (1988-05-01), Oka et al.
Konishi Masataka
Numata Ken-ichi
Oka Masahisa
Tomita Koji
Bristol-Myers Company
Kepplinger Esther M.
Morse David M.
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