Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Enzymatic production of a protein or polypeptide
Patent
1990-09-07
1992-01-07
Elmore, Carolyn
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Enzymatic production of a protein or polypeptide
435 713, 435106, 435121, C12P 2106, C12P 1716
Patent
active
050791486
ABSTRACT:
Novel peptides of the formula ##STR1## wherein R is CH.sub.3 --(CH.sub.2).sub.6, CH.sub.3 --(CH.sub.2).sub.4 --CH.dbd.CH--(CH.sub.2).sub.2 and CH.sub.3 (CH.sub.2).sub.8 having antibiotic and antitumor activity are prepared by cultivation of the novel microorganism Polyangium brachysporum. Enzymatic hydrolysis of those peptides gives other peptides useful as intermediates in the preparation of peptides having activity as antibiotics and/or antitumor agents.
REFERENCES:
patent: 4293491 (1981-10-01), Debono
patent: 4299762 (1989-11-01), Abbott et al.
patent: 4524135 (1985-06-01), Abbott et al.
patent: 4742047 (1988-05-01), Oka et al.
patent: 4916063 (1990-04-01), Oka et al.
Konishi Masataka
Numata Ken-ichi
Oka Masahisa
Tomita Koji
Bristol--Myers Squibb Company
Elmore Carolyn
Morse David M.
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