Peptide antagonists of prostaglandin F2α receptor

Details Peptide antagonists of prostaglandin F2α receptor Peptide antagonists of prostaglandin F2α receptor

2006-01-10

2006-01-10

Landsman, Robert S. (Department: 1647)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

8 to 10 amino acid residues in defined sequence

C530S300000, C530S329000, C530S333000, C514S002600

Reexamination Certificate

active

06984719

ABSTRACT:
The present invention relates to a new class of G protein-coupled receptor agonist or antagonist, which specifically binds to the receptor protein structural elements, thus altering signal transmission and subsequent physiological effects. Described herein are peptide sequences derived from the G protein-coupled receptor protein, produced by chemical methods as selective inhibitors of signal transduction associated with stimulation of the receptor by its ligand. Such peptides or molecules derived from their primary, secondary or tertiary structures may be used as effective tocolytics for the prevention of premature labor or be used for the treatment of dysmenorrhea.

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