Peptide antagonists of neurokinin B and opthalmic solutions cont

Details Peptide antagonists of neurokinin B and opthalmic solutions cont Peptide antagonists of neurokinin B and opthalmic solutions cont

1986-08-29

1988-05-03

Phillips, Delbert R.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

8 to 10 amino acid residues in defined sequence

A61K 3702, C07C10352

Patent

active

047421568

ABSTRACT:
Four decapeptides found to be analgesics and have antagonist activity to Neurokinin B which is also known as Neuromedin K. The decapeptide are of the following formula (I):

REFERENCES:
patent: 4481139 (1984-11-01), Folkers et al.
patent: 4481190 (1984-11-01), Nestor et al.
patent: 4665157 (1987-05-01), Wright
Vaught et al., "Tachykinin-Like Central Activity of Neuromedin K in Mice", European Journal of Pharmacology, 103 (1984) pp. 355-357.
Kangawa et al., "Neuromedin K: A Novel Mammalion Tachykinin Identified in Porcine Spinal Cord", Biochem. Biophys. Res. Comm., vol. 114, No. 2, 1983, pp. 533-540.
Society for Neuroscience Abstracts, vol. 10, Part 1, 14th Annual Meeting, Oct. 10-15, 1984, Anaheim, CA, No. 63.1, "Multiple Tachykinin Receptors: Substance P . . . ", Wright et al., p. 211.
Ninth American Peptide Symposium, Abstracts, U. of Toronto, Jun. 23-28, 1985, P-WTh-114, "Tachykinin Antagonists and Multiple Receptors", Wright et al.
"A Substance P Antagonist . . . ", Science, vol. 214, Nov. 27, 1981, G. Holmdahl et al., pp. 1029-1031.
"Long-Term Administration of a Substance P Antagonist . . . ", Experientia 40 (1984), Birkhauser Verlag, Switzerland, G. Bynke et al., pp. 368-369.
Munekata et al., "Neurokinin .alpha. and .beta., Synthesis and Pharmacological Properties", Chemistry Letters, pp. 1013-1016, 1984.
Vaught et al., "A Characterization of Kyotorphin (Tyr-Arg)-Induced Antinociception", European Journal of Pharmacology, 79 (1982) pp. 167-173.

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