Peptide antagonists of neurokinin B

Details Peptide antagonists of neurokinin B Peptide antagonists of neurokinin B

1985-09-30

1987-05-12

Kight, John

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

8 to 10 amino acid residues in defined sequence

C07C10352

Patent

active

046651578

ABSTRACT:
Four decapeptides found to be analgesics and have antagonist activity to Neurokinin B which is also known as Neuromedin K. The decapeptides are of the following formula (I):

REFERENCES:
patent: 4481139 (1984-11-01), Folkers et al.
patent: 4481190 (1984-11-01), Nestor et al.
Munekata et al, "Neurokinin .alpha. and .beta., Synthesis and Pharmacological Properties", Chemistry Letters, pp. 1013-1016, 1984.
Vaught et al, "A Characterization of Kyotorphin (Tyr-Arg)-Induced Antinociception", European Journal of Pharmacology, 79 (1982) 167-173.
Vaught et al, "Tachykinin-Like Central Activity of Neuromedin K in Mice", European Journal of Pharmacology, 103 (1984) 355-357.
Kangawa et al, "Neuromedin K: A Novel Mammalian Tachykinin Identified in Porcine Spinal Cord", Biochem Biophys. Res. Comm., vol. 114, No. 2, 1983, pp. 533-540.
Society for Neuroscience Abstracts, vol. 10, Part 1, 14th Annual Meeting, Anaheim, Calif., Oct. 10-15, 1984, Abstract 63.1, Multiple Tackykinin Receptors.
Ninth American Peptide Symposium Abstracts, University of Toronto, Toronto, Ontario, Canada, Jun. 23-28, 1985, Abstract P-WTh-113 Development and Modification of Competitive Antagonists of Bradykinin.

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