Peptide antagonists for the C5a anaphylatoxin

Details Peptide antagonists for the C5a anaphylatoxin Peptide antagonists for the C5a anaphylatoxin

1984-07-03

1987-09-08

Phillips, Delbert R.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

24 amino acid residues in defined sequence

530326, 530327, 530328, 530329, 530330, 530331, C07K 508, C07K 510, C07K 706, C07K 708, C07K 710

Patent

active

046925112

ABSTRACT:
Peptides and peptide compositions are disclosed which act as competitive antagonists for the C5a receptor and thus block inflammatory and immunomodulatory activity mediated by endogenous C5a.

REFERENCES:
Chem. Abstr. vol. 101, (1984) 168770d.
Chem. Abstr. vol. 93, (1980) 5893y.
Chem. Abstr. vol. 103 (1985) 86252p.
Biochem. and Biophys. Res. Commun. vol. 86, (1979) 227-234.
The Journal of Biol. Chem. vol. 253, No. 19 (1978) 6955-6964.
Chem. Abstr. vol. 88, (1978) 119258.
Biochemistry, vol. 18, No. 8, (1979) 1490-1497.
Chem. Abstr. vol. 88, (1978) 119257w; 119258x.

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