Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2001-08-02
2010-02-02
Kosar, Andrew D (Department: 1654)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C530S317000, C424S423000
Reexamination Certificate
active
07655624
ABSTRACT:
The invention relates to compounds of formula (1) B-Q-X1, wherein B is bioactive cell adhesive mediating molecule. Q is absent or is an inorganic spacer molecule and X1is an anchor molecule, selected from the group Lys-(CO—CH2—(CH2)n—PO3H2)2(I), -Lys-[-Lys-(CO—CH2—(CH2)a—PO3H2)2]2(ii) or -Lys-(Lys[-Lys-(CO—CH2—(CH2)n—PO3H2]2(iii), and n independently represents 0, 1, 2 or 3, wherein a free amino group of group B is linked in peptide form to a free carboxyl group of the spacer molecule Q or of the anchor molecule X1, or a free amino group of the radical Q is linked in peptide form to a free carboxyl group of the radical X1. The invention also relates to the salts thereof. The inventive compounds can be used as integrin inhibitors for the treatment of illnesses, deficiencies, inflammations caused by implants and osteolytic illnesses such as osteoporosis, thrombosis, cardiac infarction and arteriosclerosis, in addition to the acceleration and strengthening of the integration process of implants or the biocompatible surface in tissue.
REFERENCES:
patent: 6280760 (2001-08-01), Meyer et al.
patent: 6326403 (2001-12-01), Holzemann et al.
patent: 6610826 (2003-08-01), Meyer et al.
patent: 6649613 (2003-11-01), Holzemann et al.
patent: 43 106 43 (1994-10-01), None
patent: 197 55 800 (1999-06-01), None
patent: 198 31 710 (2000-01-01), None
patent: 19755801 (2000-06-01), None
patent: 199 32 796 (2001-01-01), None
patent: 1 309 355 (2003-05-01), None
patent: WO 2007/062525 (2007-06-01), None
Kantlehner, 1999, Angew Chem Int. Ed., 38, 560-562.
Trammell, et al., Inorganic Chemistry, 1999, vol. 38, No. 161, 3665-3669.
Nakhle B M et al., “Synthesis of 3,5-bis(phosphonomethyl) benzoic acid and its application as a metal oxide surface bivalent anchor,” Tetrahedron, Mar. 5, 1999, pp. 2835-2846, vol. 55, No. 10, XP004157121, ISSN: 0040-4020, the entire document, Elsevier Science Publishers, Amsterdam, NL.
Chu et al., “Presentation of Ligands on Hydroxylapatite,” Bioconjugate Chemistry, 1997, pp. 103-105, vol. 8, No. 2, XP002073553, ISSN: 1043-1802, p. 104, American Chemical Society, Washington, US.
J.W. Smith et al, “J. Biol. Chem.”, 1990, vol. 265, pp. 12267-12271.
P. C. Brooks et al., “Science”, 1994, vol. 264, pp. 569-571.
P. C. Brooks et al., “Cell”, 1994, vol. 79, pp. 1157-1164.
P. Valentin-Weigand et al., “Infection and Immunity”, 1988, pp. 2851-2855.
R. Keenan et al., “Abstr. Pap. 211thACS National Meeting”, 1996.
Houben-Weyl, L.C., vol. 15/11, 1974, pp. 1-806.
S. Zimmer et al., Liebigs Ann. Chem., 1993, pp. 497-501.
R. B. Merrifield et al., 1985, vol. 97, pp. 801-812.
B.F. Gysin et al., J. Am. Chem. Soc., 1972, vol. 94, pp. 3012.
G. B. Fields et al., Int. J. Pept. Protein Res., 1990, vol. 35, pp, 161-214.
Gilbert et al., “Journal of Biological Chemistry”, 2000, vol. 275, No. 21, pp. 16213-16218.
Dard Michel
Gibson Christoph
Hersel Ulrich
Hoelzemann Guenter
Kantlehner Martin
Biomet Deutschland GmbH
Gudibande Satyanarayana R
Kosar Andrew D
Millen White Zelano & Branigan P.C.
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