Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 25 or more amino acid residues in defined sequence
Patent
1991-03-08
1993-09-21
Cashion, Jr., Merrell C.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
25 or more amino acid residues in defined sequence
422 61, 530806, A61K 3702, G01N 3096
Patent
active
052470679
ABSTRACT:
The present invention relates to a peptide having the amino acid sequence: Lys Arg Ser Thr Asn, Arg Arg Tyr Lys Glu Lys Glu Lys or Ala Ile Ile Pro Asp Arg Glu Val Leu Tyr and which peptide is capable of specifically binding to the antibody which is specific to the non-A, non-B hepatitis associated antigen. The peptide can be used as an anti-HCV antibody assay reagent with high sensitivity.
REFERENCES:
J. Immun. Meth. vol. 102 (1987) pp. 259-274.
Arima et al. Gastro. Jap. vol. 25, No. 2 Apr. 1990 218-222.
Mehra et al. PNAS vol. 83, 7013-7017 (Sep. 1986).
Choo et al, Science, vol. 244, pp. 359-362 (1989).
Kuo et al, Science, vol. 244, pp. 362-364 (1989).
Arima et al, Gastroenterologia Japonica, vol. 24, No. 5, pp. 540-544; 545-548 (1989).
Chemical Abstracts, 277951y, vol. 115, Aug. 21, 1991, & EP-A-0 442 394, C. Y. Wang, "Synthetic Peptides for the Detection of Antibodies to Hepatitis C Virus (HCV), Diagnosis of HCV Infection, and Prevention Thereof as Vaccines".
Arima Terukatsu
Hatanaka Tadashi
Namba Toshihiko
Tsuji Masao
Yamada Kyoko
Arima Terukatsu
Cashion Jr. Merrell C.
Celsa Bennett
Kuraray Co. Ltd.
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