Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 24 amino acid residues in defined sequence
Patent
1993-05-21
1994-04-12
Lee, Lester L.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
24 amino acid residues in defined sequence
530326, 435 697, A61K 3700, A61K 3702, C07K 700, C12P 2106
Patent
active
053026977
ABSTRACT:
Secretory leader sequences, for use in secreting heterologous polypeptides in yeast, are formed by fusing part of the human serum albumin pre-sequence or part of the Kluyveromyces lactis killer toxin pre-sequence to the Saccharomyces cerevisiae mating factor alpha-1 KEX2 cleavage recognition site. The resulting fusion leader sequences are:
REFERENCES:
patent: 4588684 (1986-05-01), Brake
Chemical Abstract, No. JP 63133986, Dialog Information Services. "DNA sequence coding secretory signal peptide--secretes protein when DNA sequence is integrated between promoter and exotic gene in yeast host".
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Van Den Bergh et al (1987) Eur. J. Biochem. 144, 613-619.
Belfield Graham P.
Goodey Andrew R.
Sleep Darrell
Cassett Larry R.
Davenport A. M.
Delta Biotechnology Limited
Lee Lester L.
Swope R. Hain
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