Peptide analogs of bombesin

Details Peptide analogs of bombesin Peptide analogs of bombesin

1995-06-07

1998-03-03

Davenport, Avis M.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

15 to 23 amino acid residues in defined sequence

530327, 530328, A61K 3800, C07K 500, C07K 700, C07K 1700

Patent

active

057235783

ABSTRACT:
Linear peptide analogs of bombesin with modified amino acid residues at various positions. A peptide of a group of bombesin analogs according to this invention contains either a --CH.sub.2 NH.sub.2 -- pseudopeptide bond, a (3S,4S)-4-amino-3-hydroxy- 6-methylheptanoic acid residue, or a (3S,4S)-4-amino-3- hydroxy-5-phenylpentanoic acid residue.

REFERENCES:
patent: 5244883 (1993-09-01), Cai et al.
Bado et al., "Possible Mediation by Luminal Somatostatin of Bombesin-Induced Satiety in the Cat", Am. J. Physiol. 263 (Regulatory Integrative Com. Physiol. 32): R84-R88, 1992.
Coy et al., "Probing Peptide Backbone Function in Bombesin", Journal of Biological Chemistry, 11:5056-5060, 1988.
Coy et al., "Progress in the Development of Competitive Bombesin Antagonists", Annals of the New York Academy of Sciences, 547:150-157, 1988.
Coy et al., "Systematic Development of Bombesin/Gastrin-Releasing Peptide Antagonists", Journal of the National Cancer Institute Monographs, 13:133-139, 1992.
Coy et al., "Short-Chain Pseudopeptide Bombesin Receptor Antagonists with Enhanced Binding . . . ", The Journal of Biological Chemistry, 264:14691-14697, 1989.
Cuber et al., "Blockade of Bombesin Receptors with . . . ", Peptides, 11:255-258, 1990.
Dickinson et al., "Partial Agonist Activity of the Bombesin-Receptor Antagonist . . . ", Biochemical and Biophysical Research Communications, 157:1154-1158, 1988.
Edwards et al., "Potent Pseudopeptide Bombesin-like Agonists and Antagonists", Int. J. Peptide Protein Res. 43:374-383, 1994.
Mahmoud et al., "Small Cell Lung Cancer Bombesin Receptors are Antagonized By Reduced Peptide Bond Analogues" Life Sciences, 44:367-373, 1989. Small Cell Lung Cancer in Vitro and in Vivo", Cancer Research, 51:1798-1802, 1991.
Rossowski et al., "Effects of a Novel Bombesin Antagonist Analogue on Bombesin-Stimulated Gastric Acid . . . ", Scand. J. Gastroenterol, 24:121-128, 1989.
Severi et al., "Pharmacological Characterization of . . . ", The Journal of Pharmacology and Experimental Therapeutics, 251:731-717, 1989.
Trepei et al., "A Novel Bombesin Receptor Antagonist Inhibits Autocrine Signals in a Small Cell Lung Carcinoma Cell Line", Biochem. & Biophys. Res. Comm. 156:1383-1389, 1988. Specific Bombesin Receptor Antagonist in Swiss 3T3 Cells",Biochem. and Biophysical Res. Comm., 155:359-365, 1988.

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