Peptide amides and amide dimers useful as muscle relaxants

Details Peptide amides and amide dimers useful as muscle relaxants Peptide amides and amide dimers useful as muscle relaxants

1991-02-13

1993-03-02

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 18, 514906, 530330, 530331, 530323, A61K 3700, A61K 3702

Patent

active

051909243

ABSTRACT:
Peptide amide and amide dimer muscle relaxants represented by the formulae: ##STR1## wherein: R is lower alkyl; R.sub.1 and R.sub.2 independently selected from the group consisting of hydrogen, lower alkyl, allyl, propargyl, aryl lower alkyl and cyclo-lower alkyl lower alkyl, or R plus one or both of R.sub.1 and R.sub.2, together with the nitrogen to which they are attached, form a heterocyclic ring having 5 to 7 member atoms; AA are independently selected from certain amino acids moieties; n is 2 to 4; x is independently 0 or 1; y is independently 1 or 2; z is 2 to 12; and An.sup.- is a pharmaceutically acceptable anion.

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Paton et al. Pharmacological Reviews, vol. 4, (1952), pp. 219-253.
Thornber et al. NIDA Res. Monograph, 75 (Prog. Opioid Res.), (1986) pp. 181-184.
Marr-Leisy et al., Int. J. Peptide Protein Res., 25, (1985), pp. 290-296.

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