Peptide agonists of prostate-specific antigen and uses therefor

Details Peptide agonists of prostate-specific antigen and uses therefor Peptide agonists of prostate-specific antigen and uses therefor

2007-07-24

2007-07-24

Wax, Robert A. (Department: 1656)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C435S069100, C435S235100, C435S254110, C435S320100, C435S325000, C530S328000, C536S023500

Reexamination Certificate

active

10497003

ABSTRACT:
This invention relates to isolated peptides comprising agonist epitopes of prostate-specific antigen (PSA). In various aspects, the invention relates to peptides comprising agonist epitopes of the PSA-3 cytotoxic T lymphocyte epitope, and nucleic acids encoding peptides that comprise PSA-3 agonist epitopes. Also related are probes, primers, and vectors comprising these nucleic acids, as well as host cells comprising these vectors, and antibodies that bind to the PSA-3 agonist peptides. This invention further relates to diagnostic reagents and methods utilizing the disclosed nucleic acids or antibodies. The invention also relates to pharmaceutical compositions comprising the nucleic acids, host cells, and peptides of the invention, as well as methods of treatment or prevention of prostate cancer employing such compositions, for example, for peptide-mediated, cell-mediated, and vector-mediated immunotherapies.

REFERENCES:
patent: 6235486 (2001-05-01), Young et al.
patent: 97/35021 (1997-09-01), None
patent: WO 01/87325 (2001-11-01), None
Digby et al., “Human prostate specific antigen (PSA) gene: structure and linkage to the kallikrein-like gene, hGK-1,” Nucleic Acids Research, 17 (5), 2137, 1989—cited as GenBank locus HAPA4.
Dias et al., “Shotgun sequencing of the human transcriptome with ORF expressed sequence tags,” PNAS 97 (7) 3491-3496, Mar. 2000.
Digbyet al., “Human prostate specific antigen (PSA) gene: structure and linkage to the kallikrein-like gene, hGK-1,” Nucleic Acids Res. 17 (5), 2137 (1989).
Pierpaolo Correale et al., “Generation of Human Cytolytic T Lymphocyte Lines Directed Against Prostate-Specific Antigen (PSA) Employing a PSA Oligoepitope Peptide”, J. Immunol., 1998, pp. 3186-3194, vol. 161.
Pierpaolo Correale et al., “In Vitro Generation of Human Cytotoxic T Lymphocytes Specific for Peptides Derived From Prostate-Specific Antigen”, J. Nat Cancer Inst., 1997, pp. 293-300, vol. 19.
Pamela M.J. McLaughlin et al., “Cancer immunotheraphy: insights from transgenic animal models”, Critical Reviews in Oncology/Hermatology, 2001, pp. 53-76, vol. 40.
Hiroshi Terasawa et al., “Identification and Characterization of a Human Agonist Cyctotoxic T-Lymphocyte Epitope of Human Prostate-specific Antigen”, Clinical Cancer Research, Jan. 2002, pp. 41-53, vol. 8.
Slawin et al., Oct. 22, 1998, Database EMBL [Online] Prostate-specific antigen protein hK3, reprived from EMBL accession No. AAW83213, XP002409862.

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