Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues
Reexamination Certificate
2011-05-10
2011-05-10
Cordero Garcia, Marcela M (Department: 1654)
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
C530S327000, C530S328000
Reexamination Certificate
active
07939624
ABSTRACT:
The object of the present invention is the identification of a group of peptides able to break the interaction between the mutated protein p53 (hereinafter m-p53) and the proteins p63, p73 and the relative isoform proteins (hereinafter p63, p73 and p-isoforms) in the m-p53/p63, m-p53/p73 and m-p53/p-isoforms proteinic complex that has formed in the nucleus of tumor cells. Furthermore, the present invention relates to a method for causing the breakage of said proteinic complexes existing in the tumor cell lines in vitro. The present invention further relates to the use of said peptides for the preparation of a pharmaceutical composition for treating human tumors.
REFERENCES:
patent: WO 97/28186 (1997-08-01), None
patent: 9851350 (1998-11-01), None
patent: WO 99/50287 (1999-10-01), None
patent: 9966946 (1999-12-01), None
patent: 03025010 (2003-03-01), None
Blandino Giovanni
Citro Gennaro
Galati Rossella Maria
Verdina Alessandra
Cordero Garcia Marcela M
Instituti Fisioterapici Ospitalieri
Pearne & Gordon LLP
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