Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 8 to 10 amino acid residues in defined sequence
Patent
1998-08-24
2000-10-10
Russel, Jeffrey E.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
8 to 10 amino acid residues in defined sequence
562561, 562418, 562433, 562439, 562445, 562526, 562560, 564138, 564139, 564153, 564155, 564157, 564159, 564164, 564169, 564193, 564198, 514 15, 514 16, 514 17, 514 18, 514 19, 514 20, 514538, 514541, 514542, 514551, 514563, 514564, 514565, 514617, 514626, 530329, 530330, 530331, 530338, 530343, 530345, 560 19, 560 34, 560 37, 560 40, 560155, 560169, C07K 700, C07K 102, C07K 1107, C07K 506, C07K 508, C07K 510
Patent
active
061303151
ABSTRACT:
This invention relates to analogs of peptidase substrates in which the amide group containing the scissile amide bond of the substrate peptide has been replaced by an activated electrophilic ketone moiety. These analogs of the peptidase substrates provide specific enzyme inhibitors for a variety of proteases, the inhibition of which will have useful physiological consequences in a variety of disease states.
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Burkhart Joseph P.
Gerhart, deceased Fritz E.
Giroux Eugene L.
Jung Michael J.
Kolb H. Michael
Gupta Balaram
Merrell Pharmaceuticals Inc.
Russel Jeffrey E.
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